GL, or generalized lipodystrophy, is a rare and serious disease.
GL, or generalized lipodystrophy, is a rare and serious disease.
Generalized lipodystrophy (GL) is a serious, progressive, metabolic disease.1,2
GL is characterized by the widespread, permanent lack or loss of adipose tissue, resulting in deficiency of the hormone leptin. As a result, patients may experience severe metabolic abnormalities including insulin resistance, diabetes mellitus, and/or hypertriglyceridemia.
These comorbidities may put patients with GL at risk for life-threatening complications such as liver failure, renal failure, pancreatitis, and heart failure.GL is complex, heterogenous disease that can be easy to miss.2
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1. Handelsman Y, Oral EA, Bloomgarden ZT, et al. The clinical approach to the detection of lipodystrophy—an AACE consensus statement. EndocrPract. 2013;19(1):107-116.doi:10.4158/endp.19.1.v767575m65p5mr06. 2. Brown RJ, Araujo-Vilar D, Cheung PT, et al. The diagnosis and management of lipodystrophy syndromes: a multi-society practice guideline.J Clin Endocrinol Metab. 2016;101(12):4500-4511. doi:10.1210/jc.2016-2466.
